Quentin proceeded to hit a go-ahead, three-run home run during a five-run eighth inning - his second homer of the game - and Chicago charged back for an unlikely 10-8 victory over the Texas Rangers on Wednesday.

The go-ahead homer came on the first pitch from Rangers closer C.J. Wilson, who entered in relief of Eddie Guardado with two runners on and two outs.

“I was looking fastball and was going to adjust to anything he threw up there,” said Quentin, who leads the American League with 26 homers. “I was just looking to get a hit and tie the game. Sometimes in those situation when you’re not looking to do too much, good things happen.”

It was the third multihomer game of the season for Quentin, whose shot in the fifth barely cleared the wall in center field.

Alexei Ramirez singled in Paul Konerko and Orlando Cabrera drove in Ramirez with a sacrifice fly to deep left that was less than a foot from landing in the bleachers. That gave Quentin a chance to be the hero.

And to give Guillen a gift he couldn’t see in person.

The White Sox manager was ejected in the seventh with his team trailing 8-4. Guillen argued with umpire Rob Drake after a called third strike on Nick Swisher that appeared to be outside, and he was promptly sent to the clubhouse.

At the time of the comeback, Guillen was in his office packing for the team’s 10-game road trip that begins Friday at Detroit.

“They never give up,” he said. “They can play without me, but I can’t manage without them.”

Octavio Dotel (4-4) pitched a scoreless eighth and Bobby Jenks worked the ninth for his 19th save in 22 chances.

Guardado (1-2) wound up allowing four runs and three hits, retiring only two batters.

“We thought we had the game,” Rangers manager Ron Washington said. “I mean, you are up 8-5 going into the eighth inning and you bring in your two best relievers, and before you can get out of the inning they got five runs. So it was disappointing, but we’ve bounced back from disappointments before and we’ll bounce back from this one.”

The White Sox won the final two games against the Rangers to split their six-game homestand. They increased their lead atop the AL Central over Minnesota.

Rangers starter Kevin Millwood left with two outs in the second with a sore right groin. He got the first two batters out, then issued consecutive walks to No. 9 hitter Juan Uribe and Cabrera before coming out of the game.

It’s not the first time Millwood as had to deal with a groin injury. He spent three weeks on the disabled list in May for the same thing.

“It just got bad enough to the point where I couldn’t push off and I wasn’t going to do us any good that way,” said Millwood, who allowed three runs and two hits. “It’s frustrating. I just want to get it taken care of and be able to pitch without worrying about it.”

White Sox starter Clayton Richard was making his major league debut after getting called up Monday to take the spot of injured starter Jose Contreras (elbow tendinitis).

Richard worked quickly but also ran up a high pitch count. He lasted four innings, giving up seven hits and five runs. He struck out seven batters - including All-Star Josh Hamilton three times - and walked one.

Michael Young greeted Richard in the first with his eighth homer. The White Sox responded in the bottom of the inning with a three-run home run from Jim Thome, his 19th homer of the season and 526th of his career.

The Rangers tied the game at 3 with two outs in the second. Ian Kinsler doubled to center to bring home Hank Blalock, and David Murphy scored from first when Ramirez bobbled the relay throw.

Texas scored twice in the fourth on RBI singles by Murphy and Young to break a 3-3 tie. Blalock made it 6-3 in the fifth, driving home Milton Bradley with a sacrifice fly.

The Rangers scored two more in the seventh on a single by Jarrod Saltalamacchia.