MINNEAPOLIS (AP) - Frank Thomas was thankful that his family had to catch an early flight Thursday.

That meant his wife, three children and father-in-law got to see Thomas hit his 500th career home run. And they were gone when Thomas got ejected.

“They had to leave for the airport at 1:45,” he said. “My daughter said, ‘Dad, you’ve got to do it in the first couple of at-bats.’”

Thomas hit a three-run shot in the first inning of the Toronto Blue Jays’ 8-5 loss to the Minnesota Twins, becoming the 21st major leaguer to reach 500.

But in the ninth, Thomas was ejected by plate umpire Mark Wegner after being called out on strikes for the second time in the game. Jays manager John Gibbons argued and also got tossed.

“I’m probably the first to get 500 home runs and get thrown out of the ballgame,” Thomas said. “That’s something I didn’t want to happen, but the moment just got the best of me. I’ve still got hunger and desire. You saw that in the ninth. I still care.”

Thomas also had a run-scoring double and tied his season high with four RBI.

Torii Hunter homered twice and Jason Bartlett also connected for Minnesota, which rallied from a 5-1 deficit.

“You can’t upstage 500 home runs. It’s hard to do. I’ll be lucky if I hit 300,” said Hunter, who has 181 career homers.

Carlos Silva (6-8), who gave up Thomas’ milestone homer, was the winner and Joe Nathan got his 15th save. Jason Frasor (1-3) lost.

Thomas came up after Matt Stairs’ RBI single in the first and sent Silva’s 1-2 pitch an estimated 396 feet into the left-field stands.

Todd Eisenlohr, sitting in the fifth row, caught the ball in his glove. Eisenlohr said he traded the souvenir ball for an autographed ball, bat and jersey.

Thomas said he plans to keep the ball unless it is wanted by the Hall of Fame.

Before the at-bat, Thomas looked at the scoreboard and saw that his average with runners in scoring position was .182.

“I said, ‘Let’s just get a hit right here,’” he said. “That’s when home runs happen, when you’re really not trying to do too much. He hung a slider over the corner and I stayed with the pitch.”

The Metrodome crowd responded with a standing ovation for Thomas, a two-time American League MVP. He put his head down for his home run trot and then pointed toward his family down the right-field line when he crossed the plate as Toronto players came out to congratulate him.

Thomas, 39, hit his first career homer at the Metrodome against Gary Wayne while with the Chicago White Sox on Aug. 28, 1990.

Next on Thomas’ ascent on the career list are Eddie Murray (504), Mel Ott (511) and Ernie Banks and Eddie Mathews (512 each). Also within reach of 500 this year are Alex Rodriguez, Jim Thome and Manny Ramirez.

Thomas shook his head in amazement when he thought about joining Hank Aaron, Barry Bonds, Babe Ruth, Willie Mays, Harmon Killebrew and 15 others in the 500 club.

“It’s an unbelievable class of talent. I saw a lot of them play,” he said. “I have the utmost respect, and I’m very happy to be here because it takes a long time to hit 500 home runs and I think I’ve paid my dues long enough through numerous injuries.

“At one point, I didn’t think I’d ever get here because of the ankle. I’d never be back on the field.”

The injured left ankle limited Thomas to 108 combined games in 2004 and 2005, leading to his exit from Chicago, where he played the first 16 years of his career.

Thomas is in his first season with the Blue Jays. He played last year in Oakland.

“Now that I’m healthy again I would love to get to 600,” he said.

He doesn’t care that his milestone came in an era when skepticism surrounds some of the game’s most prolific home run hitters.

“This means a lot to me because I did it the right way and I’ve busted my butt since college,” he said. “I always worked hard in that weight room to be strong. I’m a big guy and I’ve been blessed with this talent.”

Thomas has hit 50 homers against the Twins, his most against any team and the most by an active player against Minnesota. Rocky Colavito hit 52 against the Twins and Mickey Mantle and Reggie Jackson each hit 51.

Reigning AL MVP Justin Morneau returned to the Minnesota lineup after missing six games with a bruised lung. He went 0-for-3 with a walk and an RBI as a designated hitter.